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Baqiyatallah University of Medical Sciences

Arglabin could target inflammasome-induced ARDS and cytokine storm associated with COVID-19

(2021) Arglabin could target inflammasome-induced ARDS and cytokine storm associated with COVID-19. Molecular Biology Reports. pp. 8221-8225. ISSN 0301-4851

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Abstract

Arglabin (l(R),10(S)-epoxy-5(S),5(S),7(S)-guaia-3(4),ll(13)-dien-6,12-olide), is a natural sesquiterpene gamma-lactone which was first isolated from Artemisia glabella. The compound has been shown to possess anti-inflammatory activity through inhibition of the NLR Family pyrin domain-containing 3 (NLRP3) inflammasome and production of proinflammatory cytokines including interleukin (IL)-1 beta and IL-18. A more hydrophilic derivative of the compound also exhibited antitumor activity in the breast, colon, ovarian, and lung cancer. Some other synthetic derivatives of the compound have also been synthesized with antitumor, cytotoxic, antibacterial, and antifungal activities. Since both NLRP3 inflammasome and cytokine storm are associated with the pathogenesis of COVID-19 and its lethality, compounds like arglabin might have therapeutic potential to attenuate the inflammasome-induced acute respiratory distress syndrome and/or the cytokine storm associated with COVID-19.

Item Type: Article
Keywords: Artemisia Asteraceae Arglabin Corona virus COVID-19 Anti-inflammation sesquiterpene lactone apoptosis cells Biochemistry & Molecular Biology
Page Range: pp. 8221-8225
Journal or Publication Title: Molecular Biology Reports
Journal Index: ISI
Volume: 48
Number: 12
Identification Number: https://doi.org/10.1007/s11033-021-06827-7
ISSN: 0301-4851
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/10028

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