Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Genetic variants and risk of thyroid cancer among Iranian patients

(2021) Genetic variants and risk of thyroid cancer among Iranian patients. Hormone Molecular Biology and Clinical Investigation. pp. 223-234. ISSN 1868-1883

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Abstract

The definition of an exclusive panel of genetic markers is of high importance to initially detect among this review population. Therefore, we gave a summary of each main genetic marker among Iranian patients with thyroid cancer for the first time which were classified based on their cellular function. Due to the results, a significant relationship was found between SNP in codons 194, 280, and 399 (XRCC1), Allele 3434Thr (XRCC7), GC or CC genotype 31, G/C (Survivin), 399G>A (XRCC1), Tru9I (vitamin D receptor), G-D haplotype (MDM2), TT genotype, -656 G/T (IL-18), TAGTT haplotype (IL-18), G allele in +49 A>G (CTLA-4), +7146 G/A (PD-1.3), +7785 C/T (PD-1.5), rs1143770 (let7a-2), rs4938723 (pri-mir-34b/c) genes, and thyroid cancers. Moreover, SNP in 677C->T (MTHFR), GG genotype Asp1312Gly (thyroglobulin), 2259C>T (Rad52), R188H, (XRCC2), T241M (XRCC3) had higher risks of thyroid cancer and lower risks were observed in -16 Ins-Pro (p53), rs3742330 (DICER1). At last, the protective effects were explored in 127 CC genotype (IL-18), rs6877842 (DROSHA). Conduct further studies on the types of DNA repair gene polymorphisms with a larger number in the thyroid cancer using modern methods such as SNP array so that these genes could be used as a biomarker in prediction, diagnosis, and treatment of thyroid cancer. This review presents for the first time a summary of important genetic markers in Iranian patients with thyroid cancer.

Item Type: Article
Keywords: biomarker genotyping Iran single nucleotide polymorphisms thyroid cancer plasminogen-activator inhibitor-1 d-receptor polymorphisms vitamin-d progesterone-receptors increasing incidence xrcc1 polymorphisms aggressive features il-18 promoter breast-cancer association Biochemistry & Molecular Biology
Page Range: pp. 223-234
Journal or Publication Title: Hormone Molecular Biology and Clinical Investigation
Journal Index: ISI
Volume: 42
Number: 2
Identification Number: https://doi.org/10.1515/hmbci-2020-0051
ISSN: 1868-1883
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/10058

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