Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The Role of exosomes in infectious diseases

(2013) The Role of exosomes in infectious diseases. Inflammation and Allergy - Drug Targets. pp. 29-37. ISSN 18715281 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

An exosome is a nano vesicle that buds from the endosomal compartment; it is produced and released by all kinds of mammalian cells. This vesicle contains a variety of proteins, lipids, mRNAs and miRNAs. These components are specific to the origin of the exosomes and contribute to cell-cell communications. Recently, it has been reported that a few single cell eukaryotic pathogens such as Cryptoccoccus neoformance and Leishmania major and donovanican secrete an exosome and influence the host immune system. In addition, it has been observed that cells infected by intracellular pathogens are capable of secreting an exosome which is involved in the fate of the infection. Furthermore, retroviruses recruit the host's endosomal compartments in order to generate viral vesicles which are similar to the exosome. Most of the exosomes involved in infectious biology can either spread or limit an infection based on the type of pathogen and its target cells. Hence, an exosome may be an appropriate candidate for a vaccine therapy in prophylaxis and treatment. © 2013 Bentham Science Publishers.

Item Type: Article
Keywords: Bacterial infection Exosome Food allergy tolerance Parasite Probiotic Viral infection acid phosphatase glucuronoxylomannan heat shock protein lactase lipid lysophospholipase messenger RNA microRNA probiotic agent protein superoxide dismutase thioredoxin thioredoxin reductase urease vaccine article cell communication Cryptococcus neoformans exocytosis human immune system immunoblotting infection Leishmania donovani Leishmania major matrix assisted laser desorption ionization time of flight mass spectrometry mycosis nonhuman parasitosis pathogenesis polyacrylamide gel electrophoresis T lymphocyte thin layer chromatography virus infection Western blotting Animals Cryptococcosis Exosomes Humans Immunotherapy, Active Leishmaniasis, Cutaneous Nanomedicine Retroviridae Retroviridae Infections
Divisions:
Page Range: pp. 29-37
Journal or Publication Title: Inflammation and Allergy - Drug Targets
Journal Index: Scopus
Volume: 12
Number: 1
Identification Number: https://doi.org/10.2174/1871528111312010005
ISSN: 18715281 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/1008

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