Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Performance and Predictive Value of First Trimester Screening Markers for Down Syndrome in Iranian Pregnancies

(2018) Performance and Predictive Value of First Trimester Screening Markers for Down Syndrome in Iranian Pregnancies. J Family Reprod Health. pp. 121-128. ISSN 1735-8949 (Print) 1735-9392

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/31223317

Abstract

Objective: To investigate the performance of first trimester Down syndrome (DS) screening markers in Iranian pregnancies.Although sonographic and serum markers are currently recommended for the first trimester screening of Down syndrome, the screening performance of the markers depends on the race and ethnicity. Materials and methods: A retrospective case-control study using first trimester screening results recorded with the prenatal diagnostic multi-centers in Iran. A total of 6,384 pregnant women were examined from March 2012 to February 2017. Totally 100 Down syndrome cases and 266 matched controls were selected and the maternal characteristics, sonographic and biochemical screening data were collected. Statistical analysis was performed using logistic regression and descriptive statistics. A decision tree model was designed using the chi-squared automatic interaction detection method based on serum markers. Results: For screening of DS pregnancies, PAPP-A (cut-off 0.795 MoM) yielded the highest sensitivity (86) and NB marker presented highest specificity (96.24). combination of the biochemical markers PAPP-A and beta-hCG (cut-off: 1.55 MoM) showed the highest sensitivity over other combined markers. The decision-tree model based on serum markers improved (91 DR For a 5 FPR) first trimester screening performance. Conclusion: The novel decision-tree model base on serum markers revealed a better predictive value to achieve high sensitivity and specificity of first trimester Down syndrome screening in Iranian population.

Item Type: Article
Keywords: Down Syndrome First Trimester Screening Serum Marker Sonographic Markers
Divisions:
Page Range: pp. 121-128
Journal or Publication Title: J Family Reprod Health
Journal Index: Pubmed
Volume: 12
Number: 3
ISSN: 1735-8949 (Print) 1735-9392
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/1395

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