Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The investigation of relevancy between PIAS1 and PIAS2 gene expression and disease severity of multiple sclerosis

(2019) The investigation of relevancy between PIAS1 and PIAS2 gene expression and disease severity of multiple sclerosis. J Immunoassay Immunochem. pp. 396-406. ISSN 1532-1819

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/31084243

Abstract

Introduction: PIAS1 and PIAS2 (protein inhibitor of activated STAT 1,2) play key roles in the pathogenesis of autoimmune and inflammatory diseases. This study aims to evaluate the gene expression of these factors in multiple sclerosis (MS) patients compared to healthy individuals and correlate them with the severity of MS. Materials and methods: Sixty participants, including 30 patients with MS and 30 healthy controls were studied. The expression of PIAS1 and PIAS2 genes in peripheral blood samples of all participants was measured by real-time PCR. The severity of MS was evaluated using the Expanded Disability Status Scale (EDSS). Finally, we evaluated the correlation between the expression of PIAS1 and PIAS2 genes with disease severity. Results: The expression of PIAS1 gene was increased in patients with MS compared to healthy subjects (P value<.001). Also, there was a significant correlation between the expression of PIAS1 and PIAS2 genes with disease severity according to EDSS. Conclusion: Our study suggests the expression of PIAS1 and PIAS2 genes as a prognostic and diagnostic marker in MS disease.

Item Type: Article
Keywords: Adult Case-Control Studies Female Gene Expression Profiling Humans Male Middle Aged Multiple Sclerosis/blood/*genetics Protein Inhibitors of Activated STAT/blood/*genetics RNA/genetics Small Ubiquitin-Related Modifier Proteins/blood/*genetics Young Adult Edss Multiple sclerosis Pias2
Divisions:
Page Range: pp. 396-406
Journal or Publication Title: J Immunoassay Immunochem
Journal Index: Pubmed
Volume: 40
Number: 4
Identification Number: https://doi.org/10.1080/15321819.2019.1613244
ISSN: 1532-1819
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/1402

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