Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Detection of common clones of Salmonella enterica serotype Infantis from human sources in Tehran hospitals

(2018) Detection of common clones of Salmonella enterica serotype Infantis from human sources in Tehran hospitals. Gastroenterol Hepatol Bed Bench. pp. 54-59. ISSN 2008-2258 (Print) 2008-2258

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/29564066

Abstract

Aim: The aims of this study were to investigate antibiotic resistance pattern and molecular characterization of Salmonella Infantis strains, isolated from human sources in Tehran hospitals from 2008 to 2010. Background: Infection caused by Salmonella is one of the major public health problems. Despite the clinical importance of Salmonella enteric subsp. enteric serovar Infantis in humans, there is no information available about the common clones of Salmonella Infantis in clinical isolates in Iran. Methods: S. Infantis strains were identified by conventional microbiological and serological testing. The antimicrobial susceptibility of the S.Infantis isolates was determined using the disk diffusion method. The genetic relatedness and the dominant clones of S. Infantis strains were detected by the Multi Locus Sequence Typing (MLST) and pulsed-field gel electrophoresis (PFGE) techniques. Results: More than 80 of the S. Infantis isolates represented multidrug-resistant patterns. PFGE revealed high genetic similarity among S. Infantis strains. While, MLST indicated high-clonal similarity among strains, where all S. Infantis strains were assigned to the ST32 sequence type. Conclusion: This is the first study in Iran conducted to determine the sequence types of S. Infantis in clinical isolates using MLST. The genetically closed MDR S. Infantis clones were responsible for the apparent endemic occurrence of salmonellosis, caused by this Salmonella serovar, in Tehran.

Item Type: Article
Keywords: Iran Multi Locus Sequence Typing Salmonella Infantis
Divisions:
Page Range: pp. 54-59
Journal or Publication Title: Gastroenterol Hepatol Bed Bench
Journal Index: Pubmed
Volume: 11
Number: 1
ISSN: 2008-2258 (Print) 2008-2258
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/1484

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