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Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The Effect of PRP-enriched Gelfoam on Chronic Tympanic Membrane Perforation: A Double-blind Randomized Clinical Trial

(2017) The Effect of PRP-enriched Gelfoam on Chronic Tympanic Membrane Perforation: A Double-blind Randomized Clinical Trial. Int Tinnitus J. pp. 108-111. ISSN 0946-5448 (Print) 0946-5448

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/29336128

Abstract

OBJECTIVE: To evaluate the effect of PRP-enriched gelfoam on the healing of chronic TM perforation in comparison with gelfoam alone. METHODS: In this double-blind randomized clinical trial Patients with chronic tympanic membrane were randomly allocated to two groups; intervention group underwent tympanoplasty with platelet rich plasma (PRP)- enriched gel foams and control group underwent operation with conventional gel foams alone. Patients information was recorded 4 and 12 months after surgery. RESULTS: Eventually 24 patients (12 males and 12 females) with a mean age of 43.33 +/- 12.34 years in intervention and 41.33 +/- 10.02 years in control group underwent analysis (p = 0.667). Complete TM healing was seen in 8 (66.67) patients in intervention group and 3 (25) patients in control group three months after intervention (p = 0.031, OR = 5.98). CONCLUSION: Addition of PRP to conventional gelfoams used in TM perforation repair increases the complete healing rate of TM perforation with less morbidity and complications.

Item Type: Article
Keywords: Adolescent Adult Chronic Disease Double-Blind Method Female Follow-Up Studies Gelatin Sponge, Absorbable/*pharmacology Hemostatics/pharmacology Humans Male Middle Aged *Platelet-Rich Plasma Retrospective Studies Treatment Outcome Tympanic Membrane/*diagnostic imaging Tympanic Membrane Perforation/diagnosis/*surgery Tympanoplasty/*methods Young Adult gelfoam platelet rich plasma tympanic membrane perforation tympanic membrane repair tympanic membrane rupture
Divisions:
Page Range: pp. 108-111
Journal or Publication Title: Int Tinnitus J
Journal Index: Pubmed
Volume: 21
Number: 2
Identification Number: https://doi.org/10.5935/0946-5448.20170021
ISSN: 0946-5448 (Print) 0946-5448
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/1504

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