(2018) ScFv Improvement Approaches. Protein Pept Lett. pp. 222-229. ISSN 0929-8665
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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/29189116
Abstract
The most common recombinant antibody format is the single chain fragment variable (scFv) which it contains the complete antigen-binding domains of an intact antibody. ScFv fragments have found vast medical and non-medical applications. Several approaches have been employed to increase the affinity, avidity and structural stability related to these antibody fragments. Most approaches related to scFv improvement have been included in this review.
| Item Type: | Article |
|---|---|
| Keywords: | Antibody Affinity Binding Sites Computer Simulation Humans Protein Conformation Protein Multimerization Protein Stability Recombinant Proteins/chemistry/genetics/immunology Single-Chain Antibodies/*chemistry/genetics/*immunology affinity antibody fragments avidity recombinant antibody scFv scFv stability. |
| Divisions: | |
| Page Range: | pp. 222-229 |
| Journal or Publication Title: | Protein Pept Lett |
| Journal Index: | Pubmed |
| Volume: | 25 |
| Number: | 3 |
| Identification Number: | https://doi.org/10.2174/0929866525666171129225436 |
| ISSN: | 0929-8665 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/1516 |
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