Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

High rates of nontuberculous mycobacteria isolation from patients with presumptive tuberculosis in Iran

(2018) High rates of nontuberculous mycobacteria isolation from patients with presumptive tuberculosis in Iran. New Microbes New Infect. pp. 12-17. ISSN 2052-2975 (Print) 2052-2975

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/29188063

Abstract

Nontuberculous mycobacteria (NTM) can cause disease which can be indistinguishable from tuberculosis (TB), posing a diagnostic and therapeutic challenge, particularly in low- and middle-income settings. We aimed to investigate the mycobacterial agents associated with presumptive clinical pulmonary TB in Iran. A total of 410 mycobacterial isolates, obtained between March 2014 and January 2016, from 7600 clinical samples taken from consecutive cases of presumptive diagnosis of TB were identified. Phenotypic and molecular tests were used to identify the isolated organisms to the species level. Single-locus and multilocus sequence analysis based on 16S rRNA, rpoB, hsp65 and ITS locus were used to confirm the results. Of 410 consecutive strains isolated from suspected TB subjects, 62 isolates (15.1) were identified as NTM. Patients with positive NTM cultures met American Thoracic Society diagnostic criteria for NTM disease. Mycobacterium simiae was the most frequently encountered (38.7), followed by Mycobacterium fortuitum (19.3), M. kansasii (17.7) and M. avium complex (8.0). Isolation of NTM, including M. simiae, from suspected TB cases is a serious public health problem and merits further attention by health authorities, physicians and microbiologists.

Item Type: Article
Keywords: Iran Mycobacterium simiae mycobacterium nontuberculous tuberculosis
Divisions:
Page Range: pp. 12-17
Journal or Publication Title: New Microbes New Infect
Journal Index: Pubmed
Volume: 21
Identification Number: https://doi.org/10.1016/j.nmni.2017.08.008
ISSN: 2052-2975 (Print) 2052-2975
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/1517

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