Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Evaluation of YKL-40 serum level in patients with type 1 diabetes and its correlation with their metabolic and renal conditions

(2017) Evaluation of YKL-40 serum level in patients with type 1 diabetes and its correlation with their metabolic and renal conditions. Nephrourol Mon. ISSN 22517006 (ISSN)

[img] Text
Evaluation of YKL-40 serum level in patients with type 1 diabetes and its correlation with their metabolic and renal conditions.pdf

Download (738kB)

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: The main indicator of long-term glycemic control in type 1 diabetes and its complications is glycosylated hemoglobin (HbA1c). Considering that there are little studies on the correlation of YKL-40 with HbA1C in type 1 diabetes, we evaluated such correlation to suggest YKL-40 as both diagnostic and prognostic marker of type 1 diabetes poor control and nephropathy. Methods: 49 patients of type 1 diabetes not suffering from any diabetic complications during recent 5 years and 43 sex- and agematched healthy controls participated in the study. Taking fasting blood and urine samples, we measured CBC, serum levels of YKL-40, HbA1c, creatinine, lipids, and urinary concentration of albumin and creatinine using standard laboratory methods. Results: Serum level of YKL-40 was significantly higher in type 1 diabetes compared to controls (P < 0.001). There was no significant correlation between such levels and HbA1c (P = 0.99) in type 1 diabetic patients. There was a strong positive correlation between YKL-40 and duration of the disease (P < 0.001).We found no significant correlation between serum level of YKL-40 and other factors including urine/albumin creatinine ratio (UACR), blood pressure, lipid profile, and serum and urine creatinine. Conclusions: Although there was a significant increase in serum level of YKL-40 in type 1 diabetic patients, it did not show any correlation with both metabolic and nephropathic states of diabetes. © 2017, Nephro-Urology Monthly.

Item Type: Article
Keywords: Diabetic nephropathy HbA1c Type 1 diabetes (T1D) YKL-40 albumin chitinase 3 like protein 1 creatinine glucose hemoglobin A1c lipid Article blood analysis blood cell count child clinical article controlled study correlation analysis creatinine blood level creatinine urine level diagnostic value diastolic blood pressure diet restriction disease duration female glycemic control human insulin dependent diabetes mellitus laboratory test lipid blood level male microalbuminuria prognosis protein blood level school child systolic blood pressure urinalysis
Divisions:
Journal or Publication Title: Nephrourol Mon
Journal Index: Scopus
Volume: 9
Number: 5
Identification Number: https://doi.org/10.5812/numonthly.12431
ISSN: 22517006 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/161

Actions (login required)

View Item View Item