Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Effects of preoperative use of oral dextromethorphan on postoperative need for analgesics in patients with knee arthroscopy

(2014) Effects of preoperative use of oral dextromethorphan on postoperative need for analgesics in patients with knee arthroscopy. Anesth Pain Med. e11187. ISSN 2228-7523 (Print) 2228-7523

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/24660143

Abstract

BACKGROUND: Studies have shown that N-methyl-D-aspartate receptor (NMIDA) plays an essential role in postoperative pain. It seems that use of NMDA receptor antagonists such as Dextromethorphan intensifies the analgesic effects of opioids. OBJECTIVES: In this study, we evaluated the effect of preoperative administration of Dextromethorphan on postoperative pain reduction. PATIENTS AND METHODS: This double blind randomized clinical trial was conducted on arthroscopic surgery candidates. Participants were randomly allocated to interventions and assigned to two groups of Dextromethorphan and placebo. In Dextromethorphan group, the patients received 1 mg/kg Dextromethorphan orally the night before the operation. Pain severity based on the visual analog scale (VAS) up to 16 hours postoperation, use of opioids, and the first request for analgesics were recorded postoperatively. RESULTS: A total of 112 patients in the Dextromethorphan (n = 54) and placebo groups (n = 58) were evaluated. No significant difference was detected between the two groups for age, sex or ASA. The mean amount of opioid consumption was significantly lower in patients who received Dextromethorphan (10.7 +/- 5.6 mg) compared to the placebo group (13.1 +/- 5.6 mg), (P = 0.03). The mean time until the first opioid request in patients who received Dextromethorphan was longer than that in the placebo group (P = 0.01). CONCLUSIONS: The study results demonstrated that preemptive use of Dextromethorphan reduced postoperative pain and opioid consumption.

Item Type: Article
Keywords: Analgesia Analgesics, Opioid Pain Postoperative Period
Divisions:
Page Range: e11187
Journal or Publication Title: Anesth Pain Med
Journal Index: Pubmed
Volume: 4
Number: 1
Identification Number: https://doi.org/10.5812/aapm.11187
ISSN: 2228-7523 (Print) 2228-7523
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/1899

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