Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Serum levels of interleukins 2, 4, 6, and 10 in veterans with chronic sulfur mustard-induced pruritus: a cross-sectional study

(2013) Serum levels of interleukins 2, 4, 6, and 10 in veterans with chronic sulfur mustard-induced pruritus: a cross-sectional study. Skinmed. pp. 205-9. ISSN 1540-9740 (Print) 1540-9740

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/24053005

Abstract

Inflammation is a key component in the pathogenesis of sulfur mustard (SM)-induced skin complications. Here, the levels of interleukin (IL) -2, IL-4, IL-6, and IL-10 were evaluated in patients with chronic SM-induced complications. Seventy-four serum samples were collected from SM-injured veterans (SM group; n = 37) and nonchemically injured patients (control group; n = 37) with skin pruritus. The levels of IL-2, IL-4, IL-6, and IL-10 were evaluated by sandwich enzyme-linked immunosorbant assay technique in both nil and mitogen medium. No significant difference was found in pruritus score between SM (74.16 +/- 5.93) and control (74.48 +/- 6.15) groups (P > .05). The mean serum concentrations of IL-2 and IL-6 were found to be significantly elevated in the control compared with the SM group (P < .05). However, no significant difference was observed between the study groups regarding serum levels of IL-4 and IL-10 (P > .05). Serum IL-2 (in both SM and control groups) and IL-6 (in the control group) concentrations were significantly correlated with pruritus score while no significant association was found for IL-4 and IL-10. Serum concentrations of IL-2, IL-6, and IL-10 are significantly decreased in SM-exposed patients with chronic pruritus. Such alterations might represent a plausible mechanism for tissue damage and skin itching following SM exposure. Therefore, variation of ILs may also contribute to skin pruritus induced by SM.

Item Type: Article
Keywords: Adult Aged Case-Control Studies Chemical Warfare Agents/poisoning Chronic Disease Cross-Sectional Studies Humans Interleukin-10/blood Interleukin-2/blood Interleukin-4/blood Interleukin-6/blood Interleukins/*blood Iran Male Middle Aged Mustard Gas/poisoning Pruritus/*blood/*chemically induced Severity of Illness Index
Divisions:
Page Range: pp. 205-9
Journal or Publication Title: Skinmed
Journal Index: Pubmed
Volume: 11
Number: 4
ISSN: 1540-9740 (Print) 1540-9740
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/1959

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