Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Chelator-free radiolabeling of dextran with 68Ga for PET studies

(2017) Chelator-free radiolabeling of dextran with 68Ga for PET studies. Journal of Radioanalytical and Nuclear Chemistry. pp. 1811-1817. ISSN 02365731 (ISSN)

[img] Text
Chelator-free radiolabeling of dextran with 68Ga for PET studies.pdf

Download (582kB)

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The possibility of 68Ga-dextran complex formation was analyzed in an HEPES-buffered (pH = 4.5) as well as in an alkaline (pH = 9) solution. The result outlined that the alkaline solution was more efficient to achieve a radiolabeling efficiency of 99 for a 5 mg ml−1 dextran solution (10 min, 90 °C). 68Ga-dextran was stable 88, 71 and 86 after 2 h at storage and toward cysteine solution and human serum, respectively. The highest ROI derived ID g−1 was found within the lungs, followed by the blood, liver, and bladder. Furthermore, a significant uptake was observed in the cartilage tissue. 68Ga-dextran excreted more by the urinary and less by the biliary pathways. © 2017, Akadémiai Kiadó, Budapest, Hungary.

Item Type: Article
Keywords: 68Ga Biodistribution Dextran PET/CT ROI chelating agent gallium gallium 68 accuracy alkalinity Article bladder blood cartilage clinical protocol complex formation controlled study hepatobiliary system imaging system isotope labeling liver lung pH positron emission tomography quality control radiation exposure radionuclide ventriculography single photon emission computed tomography urinary tract
Divisions:
Page Range: pp. 1811-1817
Journal or Publication Title: Journal of Radioanalytical and Nuclear Chemistry
Journal Index: Scopus
Volume: 311
Number: 3
Identification Number: https://doi.org/10.1007/s10967-016-5164-z
ISSN: 02365731 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/197

Actions (login required)

View Item View Item