(2017) Heterocyclic compounds: Effective α-amylase and α-glucosidase inhibitors. Current Topics in Medicinal Chemistry. ISSN 15680266 (ISSN)
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Abstract
Diabetes Mellitus (DM) is a metabolic disease characterized by high blood sugar levels. Recently, it has emerged as an important and global health problem with long-term complications and high economic burden. α-Amylase (α-Amy) and α-glucosidase (α-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level. Hence, inhibition of α-amylase and α-glucosidase plays key role in the treatment of type 2 diabetes. Heterocyclic compounds -both synthetic and naturally occurring derivatives- possess efficient biological properties. At this juncture, they have demonstrated potent inhibitory activity against α-Amy and α-Gls and were found to be versatile tools for the development of novel antidiabetic agents. © 2017 Bentham Science Publishers.
| Item Type: | Article |
|---|---|
| Keywords: | Diabetes Heterocycles Natural Products Synthesis α-Amylase α-Glucosidase acarbose acridine alkaloid alkane derivative alpha glucosidase inhibitor amylase inhibitor anthocyanin benzimidazole chromene derivative coumarin derivative flavonoid furan indole derivative polyphenol derivative pyrimidine sulfonium derivative thiadiazole derivative triazole voglibose amylase enzyme inhibitor glycosidase inhibitor heterocyclic compound cyclization drug synthesis enzyme activity enzyme inhibition fluorescence spectroscopy glucose blood level human hydrogen bond hyperglycemia IC50 non insulin dependent diabetes mellitus nonhuman Review alpha-Amylases Enzyme Inhibitors Glycoside Hydrolase Inhibitors Heterocyclic Compounds |
| Divisions: | |
| Journal or Publication Title: | Current Topics in Medicinal Chemistry |
| Journal Index: | Scopus |
| Volume: | 17 |
| Number: | 7 |
| Identification Number: | https://doi.org/10.2174/1568026616666160824104655 |
| ISSN: | 15680266 (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/200 |
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