Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Cost Assessment of Implementation of Immune Tolerance Induction in Iran

(2012) Cost Assessment of Implementation of Immune Tolerance Induction in Iran. Value Health Reg Issues. pp. 54-58. ISSN 2212-1099

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/29702827

Abstract

OBJECTIVE: A number of hemophilia A patients who receive clotting factors may develop antibodies (inhibitors) against clotting factors. The immune tolerance induction (ITI) method has proved to be a very cost-effective alternative to bypassing agents. Iran's national health authority is interested in implementing the ITI method for the management of hemophilia patients with inhibitors. The objective of this study was to calculate the breakeven point between costs attributed to the ITI method and the use of bypassing agents for the management of high-responder hemophilia patients with inhibitors. METHODS: This study assessed costs attributed to the implementation of ITI for the management of Iranian hemophilia patients with costs of high-titer and high-responding inhibitors from the perspective of the national health system. The main objective was to find the breakeven point for the ITI method in comparison with the use of bypassing medicine, recombinant factor VIIa (Novoseven). RESULTS: Based on the sensitivity analysis performed, the breakeven point mainly depends on costs of factor VIII, Novoseven, and the success rate of the ITI intervention. According to this analysis, the breakeven point of ITI and Novoseven methods varies between 16 and 34 months posttreatment. The optimized point is about 17 months posttreatment. CONCLUSIONS: Iran's national health system spends more than 24 million euros for providing bypassing agents to about 124 hemophilia patients with inhibitors. Because of limited resources available in Iran's health sector, this is a huge burden. Results of this study show that the implementation of the ITI method for the management of Iranian hemophilia patients with inhibitors is a cost-saving method and Iran's health system will recover all the expenditure related to the implementation of ITI in less than 2 years and will make a considerable saving along with providing standard care for these patients.

Item Type: Article
Keywords: Iran cost assessment hemophilia patients immune tolerance induction
Divisions:
Page Range: pp. 54-58
Journal or Publication Title: Value Health Reg Issues
Journal Index: Pubmed
Volume: 1
Number: 1
Identification Number: https://doi.org/10.1016/j.vhri.2012.03.014
ISSN: 2212-1099
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2071

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