(2010) Cadmium toxicity in spermatogenesis and protective effects of L-carnitine in adult male rats. Biol Trace Elem Res. pp. 216-25. ISSN 0163-4984
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Cadmium toxicity in spermatogenesis and protective effects of L-carnitine in adult male rats.pdf Download (384kB) |
Abstract
In this study, the effects of cadmium toxicity and the protective effects of L-carnitine on spermatogenesis in Sprague-Dawley rat were evaluated. Animals were subdivided into five groups. Cadmium chloride (1-mg/kg body weight) was injected intraperitoneally during 16 days at intervals of 48 h between subsequent treatments. L-carnitine (500 mg/kg b.w., IP) was pretreated in both of control and cadmium-injected rats. Animals were killed on day 17 after the first treatment. The left cauda epididymis was removed and immediately immersed into Hank's balanced salt solution for evaluation of sperm count and viability. Following contamination with cadmium, a decrease in the number and viability of cauda epididymis sperm, the number of cell proliferation, and Johnsen Scores in the seminiferous tubules was observed. Consequently, L-carnitine treatment caused an increase in the number and viability of cauda epididymis sperm, the number of cell proliferation, and Johnsen Scores in the cadmium-induced group.
Item Type: | Article |
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Keywords: | Animals Cadmium Chloride/*toxicity Carnitine/*pharmacology Epididymis/cytology/drug effects Male Random Allocation Rats Rats, Sprague-Dawley Sperm Count Spermatogenesis/*drug effects Spermatozoa/cytology/drug effects Testis/cytology/drug effects |
Divisions: | |
Page Range: | pp. 216-25 |
Journal or Publication Title: | Biol Trace Elem Res |
Journal Index: | Pubmed |
Volume: | 137 |
Number: | 2 |
Identification Number: | https://doi.org/10.1007/s12011-009-8577-5 |
ISSN: | 0163-4984 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.bmsu.ac.ir/id/eprint/2151 |
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