Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Seroepidemiologic study of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and syphilis infections in Iranian blood donors

(2007) Seroepidemiologic study of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and syphilis infections in Iranian blood donors. Pak J Biol Sci. pp. 4461-6. ISSN 1028-8880 (Print) 1028-8880

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/19093512

Abstract

To determine the frequency of hepatitis B, hepatitis C, Human Immunodeficiency Virus (HIV) and syphilis infections in Iranian blood donors. The prevalence of serological markers of hepatitis B, hepatitis C, HIV and syphilis infections were evaluated in 318029 consecutive volunteer blood donors attending to Tehran blood transfusion service from March 2005 to March 2006. Those positive for hepatitis B surface antigen, anti-HCV, anti-HIV1/2 and VDRL (venereal disease research laboratory) reactivity were analyzed with a second independent HBsAg enzyme immunoassay (EIA) and neutralization assay; an additional independent anti-HCV EIA and HCV-RIBA assay; second independent anti-HIV1/2 test, HIV western blot and fluorescent Treponemal Antibody Absorbed (FTA-ABS), respectively. In 318029 participants, prevalence of positive HBsAg, HCV RNA, HIV western blot and FTA-ABS was 1684 (0.487), 323 (0.093), 11 (0.003) and 19 (0.005), respectively. In 1014 subjects randomly selected from these 318029 participants, besides standard interview, physical exam and routine serologic tests; anthropometric and biochemical were studies. In this selected group frequency of HBsAg was 3 (0.29, 95 CI: 0-0.64); frequency of anti-HCV was 21 (2.07), but it was (0.09, 95 CI: 0-0.30) by confirmatory HCV RNA test; frequency of HIV-Abl, 2 was 8 (0.78), but it was 2 (0.19, 95 CI: 0-0.48) by confirmatory test; frequency of RPR was 0 (0, 95 CI: 0-0.30). Despite excluding subjects with high-risk behaviors by standard interview and physical examination, still a few asymptomatic hepatitis B, hepatitis C, HIV-infected subjects existed among volunteer blood donors with demographic and biochemical findings similar to non-infected ones.

Item Type: Article
Keywords: Adult Blood Donors/*statistics & numerical data Body Height Body Weight Female HIV Infections/*epidemiology Hepatitis B/*epidemiology Hepatitis B Surface Antigens/analysis Hepatitis C/*epidemiology Human Experimentation/statistics & numerical data Humans Incidence Iran/epidemiology Male Middle Aged Syphilis/*epidemiology
Divisions:
Page Range: pp. 4461-6
Journal or Publication Title: Pak J Biol Sci
Journal Index: Pubmed
Volume: 10
Number: 24
Identification Number: https://doi.org/10.3923/pjbs.2007.4461.4466
ISSN: 1028-8880 (Print) 1028-8880
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2183

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