Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Bioactive peptides and proteins as alternative antiplatelet drugs

(2019) Bioactive peptides and proteins as alternative antiplatelet drugs. Medicinal Research Reviews. pp. 2153-2171. ISSN 0198-6325

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Abstract

Antiplatelet drugs reduce the risks associated with atherothrombotic events and show various applications in diverse cardiovascular diseases including myocardial infarctions. Efficacy of the current antiplatelet medicines including aspirin, clopidogrel, prasugrel and ticagrelor, and the glycoprotein IIb/IIIa antagonists, are limited due to their increased risks of bleeding, and antiplatelet drug resistance. Hence, it is important to develop new effective antiplatelet drugs, with fewer side-effects. The vast repertoire of natural peptides can be explored towards this goal. Proteins and peptides derived from snake venoms and plants represent exciting candidates for the development of novel and potent antiplatelet agents. Consequently, this review discusses multiple peptides that have displayed antiplatelet aggregation activity in preclinical drug development stages. This review also describes the antiplatelet mechanisms of the peptides, emphasizing the signaling pathways intervened by them. Also, the hurdles encountered during the development of peptides into antiplatelet drugs have been listed. Finally, hitherto unexplored peptides with the potential to prevent platelet aggregation are explored.

Item Type: Article
Keywords: antiplatelet effects bioactive peptides cardiovascular disease drug discovery medicinal plants pharmacokinetic profile antimicrobial peptides platelet-aggregation heart-failure therapy apelin activation mechanisms resistance disease binding Pharmacology & Pharmacy
Divisions:
Page Range: pp. 2153-2171
Journal or Publication Title: Medicinal Research Reviews
Journal Index: ISI
Volume: 39
Number: 6
Identification Number: https://doi.org/10.1002/med.21579
ISSN: 0198-6325
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2330

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