Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Microbial metabolite effects on TLR to develop autoimmune diseases

(2019) Microbial metabolite effects on TLR to develop autoimmune diseases. Toxin Reviews. pp. 273-289. ISSN 1556-9543

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Abstract

The mammalians harbor and are exposed to various populations of microorganisms, that interact with the immune system and are able to affect the balance of immune responses. Modifications of commensal flora can result in dysregulation of immune responses. Toll-like receptors (TLRs) are not only of importance in eliciting the immune responses against pathogens, but also show a significant role in the homeostasis of commensal microbiota and in the response to hazard signals and stress. Here, we review a summary of the TLRs function and the relationship between the immune system and the microbiome in autoimmune diseases' development.

Item Type: Article
Keywords: Toll-like receptors toxins bacterial metabolites probiotic exosome toll-like-receptors intestinal epithelial-cells inflammatory-bowel-disease immune-responses dendritic cells gut microbiota staphylococcus-aureus rheumatoid-arthritis pertussis toxin innate immunity Toxicology
Divisions:
Page Range: pp. 273-289
Journal or Publication Title: Toxin Reviews
Journal Index: ISI
Volume: 38
Number: 4
Identification Number: https://doi.org/10.1080/15569543.2018.1469512
ISSN: 1556-9543
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2342

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