Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The study of genes and signal transduction pathways involved in mustard lung injury: A gene therapy approach

(2019) The study of genes and signal transduction pathways involved in mustard lung injury: A gene therapy approach. Gene. p. 15. ISSN 0378-1119

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Sulfur mustard (SM) is a destructive and harmful chemical agent for the eyes, skin and lungs that causes short-term and long-term lesions and was widely used in Iraq war against Iran (1980-1988). SM causes DNA damages, oxidative stress, and Inflammation. Considering the similarities between SM and COPD (Chronic Obstructive Pulmonary Disease) pathogens and limited available treatments, a novel therapeutic approach is not developed. Gene therapy is a novel therapeutic approach that uses genetic engineering science in treatment of most diseases including chronic obstructive pulmonary disease. In this review, attempts to presenting a comprehensive study of mustard lung and introducing the genes therapy involved in chronic obstructive pulmonary disease and emphasizing the pathways and genes involved in the pathology and pathogenesis of sulfur Mustard. It seems that, given the high potential of gene therapy and the fact that this experimental technique is a candidate for the treatment of pulmonary diseases, further study of genes, vectors and gene transfer systems can draw a very positive perspective of gene therapy in near future.

Item Type: Article
Keywords: Sulfur mustard Chronic obstructive pulmonary disease (COPD) Gene therapy growth-factor-beta hypoxia inducible factor-1-alpha obstructive pulmonary-disease vaccinia virus ankara p38 map kinase sulfur-mustard viral vectors molecular-mechanisms increased expression alkylating-agents Genetics & Heredity
Divisions:
Page Range: p. 15
Journal or Publication Title: Gene
Journal Index: ISI
Volume: 714
Identification Number: https://doi.org/10.1016/j.gene.2019.143968
ISSN: 0378-1119
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2377

Actions (login required)

View Item View Item