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Baqiyatallah University of Medical Sciences

Synthesis of Tetrahydropyrazolo 4 ',3 ':5,6 pyrano 3,4-c quinolones by Domino Knoevenagel/Hetero Diels-Alder Reactions

(2019) Synthesis of Tetrahydropyrazolo 4 ',3 ':5,6 pyrano 3,4-c quinolones by Domino Knoevenagel/Hetero Diels-Alder Reactions. Synlett. pp. 1782-1786. ISSN 0936-5214

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Abstract

An efficient Lewis acid mediated domino Knoevenagel/hetero Diels-Alder (DKHDA) reaction of pyrazolone derivatives with N-acrylated anthranilic aldehydes was developed, which afforded functionalized tetracyclic tetrahydropyrazolo4',3':5,6pyrano3,4-cquinolones. The products were formed in good yields and with excellent regio- and stereoselectivity in favor of the cis-configured isomer.

Item Type: Article
Keywords: domino reaction regioselectivity cyclizations heterocycles Diels-Alder reaction Knoevenagel reaction annulated thiopyranocoumarin derivatives pyrazole derivatives enantioselective synthesis stereoselective-synthesis cyclization reactions catalyzed synthesis in-vitro antitumor potent heterocycles Chemistry
Divisions:
Page Range: pp. 1782-1786
Journal or Publication Title: Synlett
Journal Index: ISI
Volume: 30
Number: 15
Identification Number: https://doi.org/10.1055/s-0039-1690189
ISSN: 0936-5214
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2379

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