Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Efficacy of curcumin on prevention of drug-induced nephrotoxicity: A review of animal studies

(2019) Efficacy of curcumin on prevention of drug-induced nephrotoxicity: A review of animal studies. Biofactors. pp. 690-702. ISSN 0951-6433

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Abstract

Drug-induced nephrotoxicity is a frequent serious adverse effect, contributing to morbidity and increased healthcare utilization. Prevention or reversal is key. Curcumin has useful biological features that include antioxidant, anti-inflammatory, and anticancer properties. This review covers aspects of curcumin in relation to prevention of drug-induced nephrotoxicity: dosage and schedule, effect on kidney biomarkers and histological changes, and mechanisms of curcumin's protective effects. Despite success in some animal models, human studies and clinical administration of curcumin for nephroprotection remains limited due to difficulty in achieving therapeutic levels following oral administration and in determining the optimal dosing schedule. Lack of sufficient evidence from animal studies, coupled with low systemic bioavailability, continues to limit the utilization of curcumin in addressing and controlling drug-induced nephrotoxicity. Therefore, human studies are required to fully assess and validate the therapeutic potential of curcumin.

Item Type: Article
Keywords: acute kidney injury Curcuma longa Curcumin nephroprotection nephrotoxicity gentamicin-induced nephrotoxicity cisplatin-induced nephrotoxicity fatty liver-disease nf-kappa-b oxidative stress piperine combination difluorinated curcumin phytosomal curcumin liposomal curcumin metabolic syndrome Biochemistry & Molecular Biology Endocrinology & Metabolism
Divisions:
Page Range: pp. 690-702
Journal or Publication Title: Biofactors
Journal Index: ISI
Volume: 45
Number: 5
Identification Number: https://doi.org/10.1002/biof.1538
ISSN: 0951-6433
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2388

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