Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Polyphenols targeting diabetes via the AMP-activated protein kinase pathway; future approach to drug discovery

(2019) Polyphenols targeting diabetes via the AMP-activated protein kinase pathway; future approach to drug discovery. Critical Reviews in Clinical Laboratory Sciences. pp. 472-492. ISSN 1040-8363

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Abstract

Regarding the widespread progression of diabetes, its related complications and detrimental effects on human health, investigations on this subject seems compulsory. AMP-activated protein kinase (AMPK) is a serine/threonine kinase and a key player in energy metabolism regulation. AMPK is also considered as a prime target for pharmaceutical and therapeutic studies on disorders such as diabetes, metabolic syndrome and obesity, where the body energy homeostasis is imbalanced. Following the activation of AMPK (physiological or pharmacological), a cascade of metabolic events that improve metabolic health is triggered. While there are several publications on this subject, this is the first report that has focused solely on polyphenols targeting diabetes via AMPK pathway. The multiple characteristics of polyphenolic compounds and their favorable influence on diabetes pathogenesis, as well as their intersections with the AMPK signaling pathway, indicate that these compounds have a beneficial effect on the regulation of glucose homeostasis. PPs could potentially occupy a significant position in the future anti-diabetic drug market.

Item Type: Article
Keywords: AMPK signal pathway diabetes peroxisome proliferator-activated receptor gamma phytochemicals polyphenols extract ameliorates hyperglycemia improves glucose-homeostasis insulin sensitivity skeletal-muscle signaling pathways 3t3-l1 adipocytes ppar-gamma hepatic gluconeogenesis therapeutic strategy metabolic syndrome Medical Laboratory Technology
Divisions:
Page Range: pp. 472-492
Journal or Publication Title: Critical Reviews in Clinical Laboratory Sciences
Journal Index: ISI
Volume: 56
Number: 7
Identification Number: https://doi.org/10.1080/10408363.2019.1648376
ISSN: 1040-8363
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2423

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