Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The role of epigenetic changes in preeclampsia

(2019) The role of epigenetic changes in preeclampsia. Biofactors. pp. 712-724. ISSN 0951-6433

Full text not available from this repository.

Official URL:


Preeclampsia (PE) is a disorder affecting 2-10 of pregnancies and has a major role for perinatal and maternal mortality and morbidity. PE can be occurred by initiation of new hypertension combined with proteinuria after 20 weeks gestation, as well as various reasons such as inflammatory cytokines, poor trophoblast invasion can be related with PE disease. Environmental factors can cause epigenetic changes including DNA methylation, microRNAs (miRNAs), and histone modification that may be related to different diseases such as PE. Abnormal DNA methylation during placentation is the most important epigenetic factor correlated with PE. Moreover, changes in histone modification like acetylation and also the effect of overregulation or low regulation of miRNAs or long noncoding RNAs on variety signaling pathways can be resulted in PE. The aim of this review is to describe of studies about epigenetic changes in PE and its therapeutic strategies.

Item Type: Article
Keywords: DNA methylation epigenetics histone modification microRNA preeclampsia dna methylation patterns gene-related peptide bisphenol-a nitric-oxide mesenchymal transition human placentas cord blood pregnancy expression plasma Biochemistry & Molecular Biology Endocrinology & Metabolism
Page Range: pp. 712-724
Journal or Publication Title: Biofactors
Journal Index: ISI
Volume: 45
Number: 5
Identification Number:
ISSN: 0951-6433
Depositing User: مهندس مهدی شریفی

Actions (login required)

View Item View Item