Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Saffron (Crocus sativus) aqueous extract reverses the hypothalamus-pituitary-adrenal axis activity in rat model of post-traumatic stress disorder

(2019) Saffron (Crocus sativus) aqueous extract reverses the hypothalamus-pituitary-adrenal axis activity in rat model of post-traumatic stress disorder. Revista Brasileira De Farmacognosia-Brazilian Journal of Pharmacognosy. pp. 470-476. ISSN 0102-695X

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Abstract

Crocus sativus L., Iridaceae, has been used worldwide in traditional medicinefor treatment ofsome neurological disorderssuch as depression. Post-traumatic stress disorder is a mental disorder developed in peoplewho experience stressful events. Since stress has been proposed tocause thehypothalamicpituitary-adrenal axis malfunction in post-traumatic stress disorder patients, this study aimed at investigating the effect of saffron aqueous extract on hypothalamic-pituitary-adrenal axis activity in rats of post-traumatic stress disorder model. Here, Post-traumatic stress disorder animals received an acute electro foot shock; however, 5 min before the stress session, these animals received an intracerebral-ventricular (10 mu g/rat) infusion of either saffron aqueous extract or saline. Twenty one days later, they were re-exposedto the stress box withoutinducing stress, andthen were examined for their freezing behavior. The impact of stress and saffron aqueous extract on serum corticosterone, corticotrophin releasing hormone gene expression in hypothalamus and glucocorticoid receptor gene expression in pituitary gland werethen evaluated on day 28. Intra-cerebral-ventricular injection of saffron aqueous extract resulted in an increase in serum corticosterone level and reduced symptoms of freezing behavior, and corticotrophin releasing hormone and glucocorticoid receptor gene expression in post-traumatic stress disorder groups.Saffron administration could improve the symptoms of stress-induced post-traumatic stress disorder, possiblythrough the adjustment ofhypothalamic-pituitary-adrenal axis function. (C) 2019 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.

Item Type: Article
Keywords: Post traumatic stress disorder Saffron aqueous extract Corticosterone corticotrophin releasing hormone glucocorticoid receptor freezing behavior deep brain-stimulation ptsd constituents expression responses cortisol trauma nmda Pharmacology & Pharmacy
Divisions:
Page Range: pp. 470-476
Journal or Publication Title: Revista Brasileira De Farmacognosia-Brazilian Journal of Pharmacognosy
Journal Index: ISI
Volume: 29
Number: 4
Identification Number: https://doi.org/10.1016/j.bjp.2019.01.011
ISSN: 0102-695X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2474

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