Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Metabolic phenotypes of obese, overweight, and normal weight individuals and risk of chronic kidney disease: a systematic review and meta-analysis

(2019) Metabolic phenotypes of obese, overweight, and normal weight individuals and risk of chronic kidney disease: a systematic review and meta-analysis. Archives of Endocrinology Metabolism. pp. 427-437. ISSN 2359-3997

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Abstract

Objective: Chronic kidney disease (CKD) risk is inconsistent in the normal-weight, overweight, and obese individuals due to the heterogeneity of metabolic status. This meta-analysis aimed to examine the combined effects of body mass index (BMI) and metabolic status on CKD risk. Materials and methods. The MEDLINE, EMBASE, and Web of Knowledge databases were systematically searched up to March 2019 to identify all eligible studies investigating the CKD risk (defined as GFR < 60 mL/min per 1.73 m(2) and/or microalbuminuria or proteinuria) associated with the body size phenotypes which are known as metabolically unhealthy normal-weight (MUNW), metabolically healthy overweight (MHOW), metabolically unhealthy overweight, metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO).The classification of subjects in included studies as metabolically unhealthy was based on the presence of three components of metabolic syndrome. BMI categorization was based on the criteria of included studies. The risk estimates and 95 confidence intervals (Cls) were extracted and pooled using random effects analysis. Results: A total of 9 prospective cohort studies with 128773 participants and 4797 incident cases were included in the meta-analysis. Compared with healthy normal-weight individuals as reference, MUNW and MHO subjects showed an increased risk for CKD events with a pooled RR of 1.58 (95 CI = 1.28-1.96) in MUNW and 1.55 (95 CI = 1.34-1.79) in MHO persons. Also, MHOW was at increased risk for CKD (RR = 1.34, 95 CI = 1.20-1.51). MUHO individuals were at the highest risk for the development of CKD (RR = 2.13, 95 CI = 1.66-2.72). Conclusions: Individuals with metabolic abnormality, although at normal-weight, have an increased risk for CKD. Healthy overweight and obese individuals had higher risk; refuting the notion that metabolically healthy overweight and obese phenotypes are benign conditions.

Item Type: Article
Keywords: Metabolic health obesity chronic kidney disease meta-analysis unhealthy normal-weight body-mass index healthy obesity cardiovascular-disease atherosclerosis risk natural course association inflammation adults heterogeneity Endocrinology & Metabolism
Divisions:
Page Range: pp. 427-437
Journal or Publication Title: Archives of Endocrinology Metabolism
Journal Index: ISI
Volume: 63
Number: 4
Identification Number: https://doi.org/10.20945/2359-3997000000149
ISSN: 2359-3997
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2477

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