Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Choroidal Thickness and Hemoglobin A1c Levels in Patients with Type 2 Diabetes Mellitus

(2019) Choroidal Thickness and Hemoglobin A1c Levels in Patients with Type 2 Diabetes Mellitus. Journal of Ophthalmic & Vision Research. pp. 285-290. ISSN 2008-2010

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Abstract

Purpose: The aim of this study was to assess the correlation of hemoglobin A1c (HbA1c) levels with choroidal thickness in patients with type 2 diabetes mellitus (DM) using spectral domain optical coherence tomography (SD-OCT). Methods: In this prospective case series, 180 eyes from 90 patients with type 2 DM were classified into three study groups based on HbA1c values: group 1 included patients with good glycemic control (HbA1c <= 7), group 2 included patients with moderate glycemic control (HbA1c between 7 and 8), and group 3 included patients with poor glycemic control (HbA1c >= 8). Additionally, 50 eyes from 25 non-diabetic subjects were enrolled to group 4 as a control group. Sub-foveal, nasal, and temporal choroidal thickness were measured and compared. Results: Mean central, nasal, and temporal choroidal thicknesses in diabetic patients (247.80, 238.63, and 239.30 mu m) were significantly less than non-diabetic healthy subjects (277.56, 262.92, and 266.32 mu m). Additionally, mean central, nasal, and temporal choroidal thickness values in group 4 (277.56, 262.92, and 266.32 mu m) were significantly greater than the corresponding values in group 2 (248.34, 237.55, and 236.45 mu m) and group 3 (239.81, 234.62, and 233.94 mu m), but was not significantly different from corresponding values in group 1 (259.46, 246.12, and 251.00 mu m). Conclusion: HbA1c values have a significant correlation with choroidal thickness in diabetic patients, and better glycemic control with HbA1c <= 7 may prevent choroidal thinning.

Item Type: Article
Keywords: Choroidal Thickness Diabetes Mellitus Diabetic Retinopathy Enhanced Depth Imaging Optical Coherence Tomography HbA1c macular edema retinopathy choroidopathy severity Ophthalmology
Divisions:
Page Range: pp. 285-290
Journal or Publication Title: Journal of Ophthalmic & Vision Research
Journal Index: ISI
Volume: 14
Number: 3
Identification Number: https://doi.org/10.18502/jovr.v14i3.4784
ISSN: 2008-2010
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2483

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