Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Therapeutic effects of curcumin and ursodexycholic acid on non-alcoholic fatty liver disease

(2019) Therapeutic effects of curcumin and ursodexycholic acid on non-alcoholic fatty liver disease. Biomedicine & Pharmacotherapy. p. 8. ISSN 0753-3322

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Abstract

Fatty liver disease is commonly associated with inflammation, oxidative stress and apoptosis of hepatocytes. This study was designed to investigate the combinational therapeutic effects of curcumin (CMN) and Ursodeoxycholic acid (UDCA) on non-alcoholic fatty liver disease (NAFLD). Male Wistar rats were divided into 8 groups: NAFLD-induced rats, NAFLD-induced rats + CMN, NAFLD-induced rats + UDCA, and NAFLD-induced rats that received CMN + UDCA. CMN (200 mg/kg) and UDCA (80 mg/kg) was administered orally for 14 and 28 consecutive days. Biochemical and histopathological analysis were conducted in all the groups. It was seen that co-administration of CMN and UDCA significantly reduced fatty degeneration, cellular necrosis, edema, and immune cell infiltration compared to non-treated NAFLD-induced rats. Whereas, combinational therapy caused a significant decrease in levels of SGOT and SGPT enzymes and expression of p53, caspase III, iNOS and bcl-2 mRNA and proteins, in variant with the treatment of CMN and UDCA, respectively. Co-administration of CMN and UDCA was also associated with the restoration of the levels of serum TG and HDL-C however, had no effect on LDL-C. It also resulted in an in TAC, GSH- PX, and SOD and decrease in MDA level. Our study concludes that combinational therapy of CMN and UDCA is effective for the treatment of NAFLD, as compared to their solo treatment.

Item Type: Article
Keywords: Curcumin Ursodexycholic acid NAFLD Fatty liver insulin-resistance steatohepatitis inactivation antioxidant activation steatosis markers lipids model Research & Experimental Medicine Pharmacology & Pharmacy
Divisions:
Page Range: p. 8
Journal or Publication Title: Biomedicine & Pharmacotherapy
Journal Index: ISI
Volume: 115
Identification Number: https://doi.org/10.1016/j.biopha.2019.108938
ISSN: 0753-3322
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2503

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