Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Biological properties of metal complexes of curcumin

(2019) Biological properties of metal complexes of curcumin. Biofactors. pp. 304-317. ISSN 0951-6433

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Abstract

Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. (c) 2019 BioFactors, 45(3):304-317, 2019

Item Type: Article
Keywords: curcuminoids metal complex chelation fatty liver-disease antimicrobial activities antitumor-activity palladium(ii) complexes antibacterial activity antiviral activities anticancer activity alzheimers-disease diabetes-mellitus indium curcumin Biochemistry & Molecular Biology Endocrinology & Metabolism
Divisions:
Page Range: pp. 304-317
Journal or Publication Title: Biofactors
Journal Index: ISI
Volume: 45
Number: 3
Identification Number: https://doi.org/10.1002/biof.1504
ISSN: 0951-6433
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2572

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