Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Protective effects of boron and vitamin E on ethylene glycol-induced renal crystal calcium deposition in rat

(2016) Protective effects of boron and vitamin E on ethylene glycol-induced renal crystal calcium deposition in rat. Endocr Regul. pp. 194-206. ISSN 12100668 (ISSN)

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Abstract

Objectives. Kidney stone disease is a common form of renal disease. Antioxidants, such as vitamin E (Vit E) and boron, are substances that reduce the damage caused by oxidation. Methods. Adult male rats were divided into 5 groups (n=6). In group 1, rats received standard food and water for 28 days (control group); in group 2, standard rodent food and water with 0.75 ethylene glycol/d (dissolved in drinking water) (EG Group); in group 3, similar to group 2, with 3 mg of boron/d (dissolved in water) (EG+B Group); in group 4, similar to group 2, with 200 IU of vitamin E injected intraperitoneally on the fi rst day and the 14th day, (EG+Vit E Group); in group 5, mix of groups 3 and 4, respectively (EG+B+Vit E Group). Results. Kidney sections showed that crystals in the EG group increased signifi cantly in comparison with the control group. Crystal calcium deposition score in groups of EG+B (160), EG+Vit E, and EG+B+Vit E showed a significant decrease compared to EG group. Measurement of the renal tubules area and renal tubular epithelial histological score showed the highest signifi cant dilation in the EG group. Tubular dilation in the EG+B+Vit E group decreased compared to the EG+B and EG+Vit E groups. Conclusions. Efficient effect of boron and Vit E supplements, separately and in combination, has a complimentary effect in protection against the formation of kidney stones, probably by decreasing oxidative stress. © 2016, De Gruyter Open Ltd. All Rights Reserved.

Item Type: Article
Keywords: Boron Kidney stones Oxidative stress Rat Vitamin E alpha tocopherol calcium antioxidant ethylene glycol trace element adult analytical parameters animal experiment animal model animal tissue Article controlled study crystal size ethylene glycol induced renal crystal calcium deposition immunohistochemistry kidney cortex kidney injury kidney medulla kidney tubule epithelium male nephrolithiasis nonhuman oxidation renal protection scoring system animal chemically induced drug effects kidney kidney tubule metabolism pathology Wistar rat Animals Antioxidants Kidney Calculi Kidney Tubules Rats Rats, Wistar Trace Elements
Divisions:
Page Range: pp. 194-206
Journal or Publication Title: Endocr Regul
Journal Index: Scopus
Volume: 50
Number: 4
Identification Number: https://doi.org/10.1515/enr-2016-0021
ISSN: 12100668 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/263

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