Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects

(2019) Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects. Food and Chemical Toxicology. pp. 182-191. ISSN 0278-6915

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Abstract

The liver is the most essential organ of the body performing vital functions. Hepatic disorders affect the physiological and biochemical functions of the body. These disorders include hepatitis B, hepatitis C, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), liver cirrhosis, hepatic failure and hepatocellular carcinoma (HCC). Drugs related hepatotoxicity is one of the major challenges facing by clinicians as it is a leading cause of liver failure. During post-marketing surveillance studies, detection and reporting of drug-induced hepatotoxicity may lead to drug withdrawal or warnings. Several mechanisms are involved in hepatotoxicity such as cell membrane disruption, initiating an immune response, alteration of cellular pathways of drug metabolism, accumulation of reactive oxygen species (ROS), lipid peroxidation and cell death. Curcumin, the active ingredient of turmeric and exhibits therapeutic potential for the treatment of diabetes, cardiovascular disorders and various types of cancers. Curcumin is strong anti-oxidant and anti-inflammatory effects and thus it possesses hepatoprotective properties. Despite its low bioavailability, its hepatoprotective effects have been studied in various protocols of hepatotoxicity including acetaminophen, alcohol, lindane, carbon tetrachloride (CCL4), diethylnitrosamine and heavy metals induced hepatotoxicities. This report reviews the hepatoprotective effects of curcumin with a focus on its mechanistic insights in various hepatotoxic protocols.

Item Type: Article
Keywords: Curcumin Hepatoprotective Mechanistic insights Therapeutic role Drug of future induced oxidative stress induced liver-injury antiinflammatory activities acetaminophen hepatotoxicity virus-infection oxidant stress heavy-metals double-blind fatty liver in-vitro Food Science & Technology Toxicology
Divisions:
Page Range: pp. 182-191
Journal or Publication Title: Food and Chemical Toxicology
Journal Index: ISI
Volume: 124
Identification Number: https://doi.org/10.1016/j.fct.2018.12.002
ISSN: 0278-6915
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2722

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