Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Role of oxidative stress and antioxidant therapy in acute and chronic phases of sulfur mustard injuries: a review

(2019) Role of oxidative stress and antioxidant therapy in acute and chronic phases of sulfur mustard injuries: a review. Cutaneous and Ocular Toxicology. pp. 9-17. ISSN 1556-9527

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Abstract

Sulfur mustard (SM) is a chemical compound that preferentially targets ocular, cutaneous and pulmonary tissues. Although pathologic effect of SM has been extensively considered, molecular and cellular mechanism of its toxicity, especially at the chronic phase of injury is not well-understood. Excessive production of reactive oxygen species (ROS) and oxidative stress (OS) appears to be involved in SM-induced injuries. SM may trigger several molecular and cellular pathways linked to OS and inflammation that can subsequently result in cell death and apoptosis. At the acute phase of injury, SM can enhance ROS production and OS by reducing the activity of antioxidants, depletion of intercellular glutathione (GSH), decreasing the productivity of GSH-dependent antioxidants, mitochondrial deficiency, accumulation of leukocytes and pro-inflammatory cytokines. Overexpression of ROS producing enzymes and down-regulation of antioxidant enzymes are probably the major events by which SM leads to OS at the chronic phase of injury. Therefore, antioxidant therapy with potent antioxidants such as N-acetylcysteine and curcumin may be helpful to mitigate SM-induced OS damages. This review aims to discuss the proposed cellular and molecular mechanisms of acute and delayed SM toxicity, the importance of OS and mechanisms by which SM increases OS either at the acute or chronic phases of injuries along with research on antioxidant therapy as a suitable antidote.

Item Type: Article
Keywords: Sulfur mustard oxidative stress reactive oxygen species antioxidant therapy chronic pulmonary complications long-term complications skin epidermal-cells induced dna-damage quality-of-life n-acetylcysteine human airway vitamin-e bronchiolitis obliterans cutaneous complications Ophthalmology Toxicology
Divisions:
Page Range: pp. 9-17
Journal or Publication Title: Cutaneous and Ocular Toxicology
Journal Index: ISI
Volume: 38
Number: 1
Identification Number: https://doi.org/10.1080/15569527.2018.1495230
ISSN: 1556-9527
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2746

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