Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Rutin as Neuroprotective Agent: From Bench to Bedside

(2019) Rutin as Neuroprotective Agent: From Bench to Bedside. Current Medicinal Chemistry. pp. 5152-5164. ISSN 0929-8673

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Abstract

Flavonoids are major dietary constituents of plant-based food found ubiquitously in plant kingdom where they are usually present in substantial amounts. Rutin is a flavonol-type polyphenol which consists of the flavonol quercetin and the disaccharide rutinose. Rutin has been reported to exert diverse biological effects such as antitumor and antimicrobial mainly associated to its antioxidant and anti-inflammatory activities. Mental, neurological, and behavioural disorders are an important and growing cause of morbidity. Most of these disorders combine a high prevalence, early onset, progressive clinical course, and impairment of critical brain functions making them a major contributor to the global disease burden. In the present work, the biological in vitro and in vivo effects and the potential therapeutic applications of rutin in neurodegenerative processes are reviewed, as well as their bioavailability and pharmacokinetics, which are essential for a better understanding of its biological effectiveness. Moreover, the present review also provides an overview of the molecular mechanisms through which rutin is proposed to exert its neuroprotective effects.

Item Type: Article
Keywords: Alzheimer's disease antioxidant flavonoid neurodegenerative diseases polyphenols rutin spatial memory impairment oxidative stress quercetin glycosides alzheimers-disease nitric-oxide cognitive dysfunction induced neurotoxicity fagopyrum-esculentum oral bioavailability cerebral-ischemia Biochemistry & Molecular Biology Pharmacology & Pharmacy
Divisions:
Page Range: pp. 5152-5164
Journal or Publication Title: Current Medicinal Chemistry
Journal Index: ISI
Volume: 26
Number: 27
Identification Number: https://doi.org/10.2174/0929867324666171003114154
ISSN: 0929-8673
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2772

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