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Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Involvement of CA1 GABA(A) Receptors in Ketamine-Induced Impairment of Spatial and Non-Spatial Novelty Detection in Mice

(2019) Involvement of CA1 GABA(A) Receptors in Ketamine-Induced Impairment of Spatial and Non-Spatial Novelty Detection in Mice. Neurochemical Journal. pp. 81-89. ISSN 1819-7124

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Abstract

Inhibitory GABAergic and excitatory glutamatergic neurons from multiple brain areas, send fibers to the hippocampal CA1 region. NMDA receptors have been identified as important compoents of the brain system underlying memory formation, which that through an increase in glutamate-mediated neurotransmission. Ketamine and other NMDA receptor antagonists produce deficits in cognitive tasks, including both spatial and non-spatial memory. In the current study, we tested whether the activation or inhibition of GABA(A) receptors in CA1 hippocampal of mice has an impact on ketamine (NMDA antagonist) induced spatial and non-spatial novelty detection deficits. Adult male mice weighing between 25-30 g were used. The open-field method was used to evaluate spatial and non-spatial memory information. Data obtained from the present study revealed that an intra-CA1 injection with a sub-threshold dose the GABA(A) receptor antagonist bicuculline (0.0625 mu g mouse) disrupted spatial memory but restored non-spatial memory induced by lower and higher doses of ketamine (0.05 and 0.01 mg/kg) respectively. Meanwhile, the co-administration of the intra-CA1 injection with a sub-threshold dose of muscimol (GABA(A) receptor agonist at 0.25 mu g/mouse) and a lower dose of ketamine could only impair the ability of non-spatial change detection but could not alter spatial novelty. In conclusion, ketamine (which contributes to the impairment of memory trace stored in the hippocampus) may be generated from GABA(A) receptors of CA1 neurons and their blockade could prevent these effects.

Item Type: Article
Keywords: bicuculline CA1 GABA(A) ketamine muscimol spatial memory synaptic plasticity memory expression inactivation excitability resveratrol performance scopolamine antagonists modulation Neurosciences & Neurology
Divisions:
Page Range: pp. 81-89
Journal or Publication Title: Neurochemical Journal
Journal Index: ISI
Volume: 13
Number: 1
Identification Number: https://doi.org/10.1134/s1819712419010094
ISSN: 1819-7124
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2826

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