Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Lamivudine's efficacy and safety in preventing mother-to-child transmission of hepatitis B: A meta-analysis

(2019) Lamivudine's efficacy and safety in preventing mother-to-child transmission of hepatitis B: A meta-analysis. Turkish Journal of Gastroenterology. pp. 66-74. ISSN 1300-4948

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Abstract

Background/Aims: Mother-to-child transmission (MTCT) is a common transmission mode of hepatitis B virus (HBV). It has been shown that the infection may occur in some infants despite the use of immunoprophylaxis, and many studies have demonstrated the efficacy of antivirals such as lamivudine to reduce such events. Materials and Methods: A meta-analysis was conducted concerning the efficacy and safety of lamivudine during pregnancy, in the prevention of vertical transmission of HBV infection. Studies were identified by searching various databases up to January 2016 for variations of the following phrase: "lamivudine AND (pregnancy or pregnant) AND (HBV or hepatitis)." Subjects who had received lamivudine were included in the case group, and those who had not were included in the control group. Results: Our search identified a total number of 881 citations, of which 25 studies (with a total number of 2,667 pregnant women) were included in the meta-analysis. The analysis showed a significant difference between the seropositive HBsAg infants from the case and control groups (RR = 16.97, 95 confidence interval 8.36-34.45), which is the most critical factor in determining the MTCT of HBV. No significant difference was reported between the prevalence of side effects in the case and control groups. Conclusion: This meta-analysis strongly suggests the use of lamivudine in the prevention of HBV vertical transmission in carrier pregnant women with the HBV DNA levels greater than 106 copies/mL. And for women with the HBV viral loads lower than 106 copies/mL, we suggest clinicians to examine the use of lamivudine on a case-to-case basis, noting that lamivudine seems to be a safe drug for the mother and the fetus.

Item Type: Article
Keywords: Lamivudine hepatitis B pregnancy mother-to-child transmission anti-retroviral agents fetomaternal infection perinatal transmission antiviral therapy late pregnancy vertical transmission surface-antigen virus interruption failure immunoprophylaxis telbivudine Gastroenterology & Hepatology
Divisions:
Page Range: pp. 66-74
Journal or Publication Title: Turkish Journal of Gastroenterology
Journal Index: ISI
Volume: 30
Number: 1
Identification Number: https://doi.org/10.5152/tjg.2018.18148
ISSN: 1300-4948
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2844

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