Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics

(2019) Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics. Theranostics. pp. 1923-1951. ISSN 1838-7640

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Abstract

Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide, underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is an eminent component of traditional Chinese and Ayurvedic medicine for more than 2000 years. Recently, BBR has attracted much interest for its pharmacological actions in treating and/or managing CVMD. Recent discoveries of basic, translational and clinical studies have identified many novel molecular targets of BBR (such as AMPK, SIRT1, LDLR, PCSK9, and PTP1B) and provided novel evidences supporting the promising therapeutic potential of BBR to combat CVMD. Thus, this review provides a timely overview of the pharmacological properties and therapeutic application of BBR in CVMD, and underlines recent pharmacological advances which validate BBR as a promising lead drug against CVMD.

Item Type: Article
Keywords: berberine cardiovascular diseases metabolic diseases targets therapeutics activated protein-kinase fatty liver-disease low-density-lipoprotein nf-kappa-b endothelial progenitor cells ischemia-reperfusion injury smooth-muscle-cells red yeast rice cardiac ischemia/reperfusion injury nlrp3 inflammasome activation Research & Experimental Medicine
Divisions:
Page Range: pp. 1923-1951
Journal or Publication Title: Theranostics
Journal Index: ISI
Volume: 9
Number: 7
Identification Number: https://doi.org/10.7150/thno.30787
ISSN: 1838-7640
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2845

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