Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Anti-Angiogenic Activity of Curcumin in Cancer Therapy: A Narrative Review

(2019) Anti-Angiogenic Activity of Curcumin in Cancer Therapy: A Narrative Review. Current Vascular Pharmacology. pp. 262-269. ISSN 1570-1611

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Abstract

Curcumin is a naturally occurring polyphenol isolated from Curcuma longa that has various pharmacological activities, including, anti-inflammatory, anti-oxidant and anti-cancer properties. The anticancer effect of curcumin is attributed to activation of apoptotic pathways in cancer cells, as well as inhibition of inflammation and angiogenesis in the tumour microenvironment and suppression of tumour metastasis. Angiogenesis, which is the formation of new blood vessels from pre-existing ones, is a fundamental step in tumour growth and expansion. Several reports have demonstrated that curcumin inhibits angiogenesis in a wide variety of tumour cells through the modulation of various cell signaling pathways which involve transcription factors, protein kinases, growth factors and enzymes. This review provides an updated summary of the various pathways and molecular targets that are regulated by curcumin to elicit its anti-angiogenic activity.

Item Type: Article
Keywords: Curcuminoids neovascularization cancer vascular endothelial growth factor angiogenesis obesity inflammatory cytokines cxcl1 down-regulation inhibits proliferation endothelial-cells oxidative stress metastasis invasion expression suppresses bisdemethoxycurcumin Pharmacology & Pharmacy Cardiovascular System & Cardiology
Divisions:
Page Range: pp. 262-269
Journal or Publication Title: Current Vascular Pharmacology
Journal Index: ISI
Volume: 17
Number: 3
Identification Number: https://doi.org/10.2174/1570161116666180209113014
ISSN: 1570-1611
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2854

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