Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Transplantation of Human Chorion-Derived Cholinergic Progenitor Cells: a Novel Treatment for Neurological Disorders

(2019) Transplantation of Human Chorion-Derived Cholinergic Progenitor Cells: a Novel Treatment for Neurological Disorders. Molecular Neurobiology. pp. 307-318. ISSN 0893-7648

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Transplantation of Human Chorion-Derived Cholinergic Progenitor Cells a Novel Treatment for Neurological Disorders vol 56, pg 307, 2018.pdf

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Abstract

A neurological disorder is any disorder or abnormality in the nervous system. Among different neurological disorders, Alzheimer's disease (AD) is recognized as the sixth leading cause of death globally. Considerable research has been conducted to find pioneer treatments for this devastating disorder among which cell therapy has attracted remarkable attentions over the last decade. Up to now, targeted differentiation into specific desirable cell types has remained a major obstacle to clinical application of cell therapy. Also, potential risks including uncontrolled growth of stem cells could be disastrous. In our novel protocol, we used basal forebrain cholinergic progenitor cells (BFCN) derived from human chorion-derived mesenchymal stem cells (hC-MSCs) which made it possible to obtain high-quality population of cholinergic neurons and in vivo in much shorter time period than previous established methods. Remarkably, the transplanted progenitors fully differentiated to cholinergic neurons which in turn integrated in higher cortical networks of host brains, resulting in significant improvement in cognitive assessments. This method may have profound implications in cell therapies for any other neurodegenerative disorders.

Item Type: Article
Keywords: Neurological disorder Alzheimer's disease Stem cells Basal forebrain cholinergic progenitor cells neural stem-cells alzheimers-disease cognitive function neurons therapy model system gdnf Neurosciences & Neurology
Divisions:
Page Range: pp. 307-318
Journal or Publication Title: Molecular Neurobiology
Journal Index: ISI
Volume: 56
Number: 1
Identification Number: https://doi.org/10.1007/s12035-018-0968-1
ISSN: 0893-7648
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/2876

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