Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Effects of silver nanoparticles on lipid peroxidation and quality of sperm parameters in male rats

(2016) Effects of silver nanoparticles on lipid peroxidation and quality of sperm parameters in male rats. Journal of Babol University of Medical Sciences. pp. 48-55. ISSN 15614107 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

BACKGROUND AND OBJECTIVE: Considering the role of silver nanoparticles in inducing the production of free radicals, these compounds may lead to pathological effects and oxidative stress in the seminal fluid, resulting in the reduced quality of sperm parameters. Therefore, in this study, we aimed to assess the toxic effects of silver nanoparticles on sperm parameters and lipid peroxidation of sperm membranes in male rats. METHODS: This experimental study was conducted on 24 Syrian adult male rats, which were randomly divided into one control and three study groups. The rats in the study groups were orally administered silver nanoparticles at concentrations of 0.07 μg (group A), 0.14 μg (group B), and 0.28 μg (group C), respectively per day for a period of five weeks. Then, lipid peroxidation of sperm membranes was analyzed, using thiobarbituric acid assay. Additionally, microscopic examinations were performed to evaluate sperm parameters. FINDINGS: Based on the findings, the mean quality of sperm parameters such as sperm count and motility significantly declined in the study groups, particularly group B (77.69±16.96; 16±2.6×106/ml) and group C (72.79±14.52; 13.31±2.1×106/ml), compared to the control group (89.06±10.97; 23.57±3.46×106/ml) (p<0.05). Also, in terms of malondialdehyde concentration, a significant difference was reported among group A (0.25±0.01), group B (0.32±0.02), group C (0.35±0.01), and the control group (0.24±0.01) (p<0.001). CONCLUSION: The results of the present study confirmed that silver nanoparticles through enhancing lipid peroxidation could reduce the quality of sperm parameters in a dose-dependent manner. © 2016, Babol University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: Lipid peroxidation Male rats Silver nanoparticles Sperm parameters malonaldehyde silver nanoparticle thiobarbituric acid adult animal experiment Article concentration (parameters) controlled study dose response experimental study male microscopy nonhuman rat sperm quality spermatozoon count spermatozoon motility
Divisions:
Page Range: pp. 48-55
Journal or Publication Title: Journal of Babol University of Medical Sciences
Journal Index: Scopus
Volume: 18
Number: 2
ISSN: 15614107 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/313

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