Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Application of Cox and parametric survival models to assess social determinants of health affecting three-year survival of breast cancer patients

(2016) Application of Cox and parametric survival models to assess social determinants of health affecting three-year survival of breast cancer patients. Asian Pacific Journal of Cancer Prevention. pp. 311-316. ISSN 15137368 (ISSN)

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Abstract

Breast cancer is one of the most common causes of cancer mortality in Iran. Social determinants of health are among the key factors affecting the pathogenesis of diseases. This cross-sectional study aimed to determine the social determinants of breast cancer survival time with parametric and semi-parametric regression models. It was conducted on male and female patients diagnosed with breast cancer presenting to the Cancer Research Center of Shohada-ETajrish Hospital from 2006 to 2010. The Cox proportional hazard model and parametric models including the Weibull, log normal and log-logistic models were applied to determine the social determinants of survival time of breast cancer patients. The Akaike information criterion (AIC) was used to assess the best fit. Statistical analysis was performed with STATA (version 11) software. This study was performed on 797 breast cancer patients, aged 25-93 years with a mean age of 54.7 (±11.9) years. In both semi-parametric and parametric models, the three-year survival was related to level of education and municipal district of residence (P < 0.05). The AIC suggested that log normal distribution was the best fit for the three-year survival time of breast cancer patients. Social determinants of health such as level of education and municipal district of residence affect the survival of breast cancer cases. Future studies must focus on the effect of childhood social class on the survival times of cancers, which have hitherto only been paid limited attention. © 2016, Asian Pacific Journal of Cancer Prevention.

Item Type: Article
Keywords: Breast cancer Iran Parametric survival Social determinants of health adult aged breast tumor cancer staging cross-sectional study female follow up human male middle aged mortality pathology prognosis proportional hazards model risk factor statistical distribution statistics and numerical data survival rate very elderly Aged, 80 and over Breast Neoplasms Cross-Sectional Studies Follow-Up Studies Humans Neoplasm Staging Proportional Hazards Models Risk Factors Statistical Distributions
Divisions:
Page Range: pp. 311-316
Journal or Publication Title: Asian Pacific Journal of Cancer Prevention
Journal Index: Scopus
Volume: 17
Identification Number: https://doi.org/10.7314/APJCP.2016.17.S3.311
ISSN: 15137368 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/339

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