(2018) Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate. Data in Brief. pp. 596-601. ISSN 2352-3409
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Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate.pdf Download (633kB) |
Abstract
Ceramide pathway is a key regulator in cell proliferation and apoptosis and oxidative stress up-regulate ceramides. Acid ceramidase (ACDase), neutral sphingomyelinase (NSMase) and glucosylceramide synthase (GCS) are critical enzymatic systems in ceramide metabolism. Our data represent the comparative assessment of Hesperetin (Hst) and hesperetin-7-O-acetate (HTA) effects on A-494 renal carcinoma cells include cell survival, caspase-3 and 9 activities, total cellular ceramide and the activities of ACDase, NSMase, GCS and superoxide dismutase (SOD). Data reveals potentiating effects of both HTA and Hst on ceramide pathway and may offer a novel tool in human renal cell carcinoma therapy. (C) 2018 The Authors. Published by Elsevier Inc.
| Item Type: | Article |
|---|---|
| Keywords: | Hesperetin Ceramide Ceramidase Sphingomyelinase Superoxide dismutase assay Science & Technology - Other Topics |
| Divisions: | |
| Page Range: | pp. 596-601 |
| Journal or Publication Title: | Data in Brief |
| Journal Index: | ISI |
| Volume: | 20 |
| Identification Number: | https://doi.org/10.1016/j.dib.2018.08.065 |
| ISSN: | 2352-3409 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/3581 |
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