Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Electrochemical sensor based on gold nanoparticle-multiwall carbon nanotube nanocomposite for the sensitive determination of docetaxel as an anticancer drug

(2018) Electrochemical sensor based on gold nanoparticle-multiwall carbon nanotube nanocomposite for the sensitive determination of docetaxel as an anticancer drug. Ionics. pp. 3209-3219. ISSN 0947-7047

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Abstract

For the first time, a sensitive and selective method for determination of docetaxel (as an anti-cancer drug) at gold nanoparticle-multiwall carbon nanotubes/glassy carbon electrode (Au-MWCNTs/GCE) was suggested using cyclic voltammetry and differential pulse anodic stripping voltammetry (DPASV) method. After the construction of the electrochemical sensor and optimization of the effective parameters such as pH, accumulation time, and potential, the sensor was applied for the determination of docetaxel in the range of 0.3-3.3 mu mol L-1. The results show that Au-MWCNTs significantly catalyzed the redox reaction of docetaxel during electrochemical detection. The limit of detection was estimated to be 90 nmol L-1 based on 3S(b)/m. The performed studies showed that Au-MWCNTs/GCE has a good selectivity, sensitivity, and reproducibility. This sensor was used to determine the docetaxel in real samples (human urine and human serum), and the obtained data illustrate that fabricated electrochemical sensor is promising for use in routine analytical applications.

Item Type: Article
Keywords: Modified electrodes Electrochemical sensors Docetaxel Gold nanoparticles Electrocatalytic determination performance liquid-chromatography selective potentiometric sensor paste electrode biological-fluids mass-spectrometry voltammetric determination nonenzymatic detection human plasma ms/ms method pvc matrix Chemistry Electrochemistry Physics
Divisions:
Page Range: pp. 3209-3219
Journal or Publication Title: Ionics
Journal Index: ISI
Volume: 24
Number: 10
Identification Number: https://doi.org/10.1007/s11581-018-2517-3
ISSN: 0947-7047
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/3591

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