Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Nigella sativa and Non-Alcoholic Fatty Liver Disease: A Review of the Current Evidence

(2018) Nigella sativa and Non-Alcoholic Fatty Liver Disease: A Review of the Current Evidence. Hepatitis Monthly. p. 4. ISSN 1735-143X

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Abstract

Context: Nigella sativa (NS) has been used as an herbal remedy for the treatment and prevention of a variety of diseases. In this review, we aimed to summarize the current evidence on the effects of NS consumption on non-alcoholic fatty liver disease (NAFLD) characteristics. Evidence Acquisition: We reviewed the existing literature published by the end of 2017 using the following key words: "Nigella sativa", "black seeds", "black cumin", "thymoquinone", "NAFLD", "NASH", and "diabetes". Papers used in this study were collected by searching the PubMed, Google Scholar, Science Direct and Scopus databases. Our search was limited to English-language articles. All the articles published between 2000 and 2017 meeting the inclusion criteria were included in the study. Results: The results of current studies indicate that NS has many biological effects such as anti-inflammatory, anti-hyperlipidemic, anti-microbial, anti-cancer, anti-oxidative, anti-diabetic, anti-hypertensive and wound healing activities. In summary, it can be used as a valuable plant for designing therapeutic strategies in NAFLD. Conclusions: Results from available studies indicate that NS can ameliorate the main metabolic disturbances related to NAFLD including hyperglycemia, hyperlipidemia, and overweight. These effects are mainly attributed to the anti-oxidative and antiinflammatory properties of thymoquinone. Clinical trials on human subjects are highly essential to confirm the results found in in vivo and in vitro studies.

Item Type: Article
Keywords: Nigella sativa NAFLD NASH Fatty Liver oxidative stress double-blind resveratrol supplementation synbiotic supplementation insulin-resistance black cumin thymoquinone rats pilot seeds Gastroenterology & Hepatology
Divisions:
Page Range: p. 4
Journal or Publication Title: Hepatitis Monthly
Journal Index: ISI
Volume: 18
Number: 10
Identification Number: https://doi.org/10.5812/hepatmon.68046
ISSN: 1735-143X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/3594

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