Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Targeting ERK signaling pathway by polyphenols as novel therapeutic strategy for neurodegeneration

(2018) Targeting ERK signaling pathway by polyphenols as novel therapeutic strategy for neurodegeneration. Food and Chemical Toxicology. pp. 183-195. ISSN 0278-6915

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Abstract

Numerous chemicals, such as phenolic compounds are strong radical scavengers, capable of alleviating oxidative stress induced neurodegeneration. Dietary antioxidants, especially flavonoids, are being considered as a promising approach to prevent or slow the pathological development of neurological illness and aging. One of the major advantage of natural products is that of their anti-amyloid effects over synthetic counterpart, however a healthy diet provides these beneficial natural substances as nutraceuticals. The extracellular-signal-regulated kinase (ERK) is one of the main pharmacological target of natural phenolic compounds, participating in several therapeutic effects. Mounting evidence revealed that numerous bioflavonoids, obtained from a variety of dietary fruits or plants as well as medicinal herbal sources, exhibit protective or therapeutic functions versus development of neurodegenerative diseases mainly through modulation of different compartments of ERIC signaling pathway. Currently, there is remarkable interest in the beneficial effects of natural flavonoids to improve neural performance and prevent the onset and development of major neurodegenerative diseases. Natural products originated from medicinal plants, in particular antioxidants, have gained a great deal of attention due to their safe and non-toxic natures. Here, we summarized the effect of natural bioflavonoids on ERIC signaling pathway and their molecular mechanism.

Item Type: Article
Keywords: Neurodegenerative diseases Flavonoids Natural products MAPK ERK MEK/ERK activated protein-kinases parkinsons-disease model induced cell-death oxidative stress mouse model astroglial activation ischemia-reperfusion glucose-metabolism medicinal-plants brain insulin Food Science & Technology Toxicology
Divisions:
Page Range: pp. 183-195
Journal or Publication Title: Food and Chemical Toxicology
Journal Index: ISI
Volume: 120
Identification Number: https://doi.org/10.1016/j.fct.2018.07.010
ISSN: 0278-6915
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/3599

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