Abstract

In this study, we describe a modification of a glassy carbon electrode with an ordered mesoporous carbon (OMC)/poly (2-hydroxyethyl methacrylate) (PHEMA)/Ag nanoparticle composite (GCE/AgNPs-PHEMA-CMK-1) done for the first time and the application of a proposed sensor for the simultaneous determination of acetaminophen (AC) and domperidone (DO). The transmission electron microscopy (TEM), fourier-transform infrared spectroscopy (FT-IR), electrochemical impedance spectroscopy (EIS), UV-vis spectroscopy, and X-ray powder diffraction (XRD) methods were used for the analysis of the synthesized nanocomposite. The GCE/AgNPs-PHEMA-CMK-1 showed good catalytic activity for the electro-oxidation of acetaminophen and domperidone in the buffer solution. The pH investigation showed that acetaminophen and domperidone electro-oxidation is relative to the pH value of the solution. The maximum oxidation process occurred at pH=7.0 and pH=8.0 for acetaminophen and domperidone, respectively, on the surface of the GCE/AgNPs-PHEMA-CMK-1. The GCE/AgNPs-PHEMA-CMK-1 showed a linear range between 0.015-7.5M and 0.03-10.8M for acetaminophen and domperidone, respectively. The GCE/AgNPs-PHEMA-CMK-1 showed detection limits of 0.005 and 0.01M for acetaminophen and domperidone, respectively, by the differential pulse voltammetry (DPV) method. Finally, the GCE/AgNPs-PHEMA-CMK-1 was suggested as a highly powerful tool for the analysis of acetaminophen and domperidone in real samples.