Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Evidence and prospective of plant derived flavonoids as antiplatelet agents: Strong candidates to be drugs of future

(2018) Evidence and prospective of plant derived flavonoids as antiplatelet agents: Strong candidates to be drugs of future. Food and Chemical Toxicology. pp. 355-367. ISSN 0278-6915

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Platelets are involved in hemostasis, inflammation, and thrombosis processes. Following a vascular damage, the endothelium releases protein factors, allowing the adhesion of subendothelium to platelets. Then platelets are activated, leading to the secretion of biologically-active ligands including thromboxane A2, adenosine diphosphate and serotonin. Aspirin, clopidogrel and warfarin are the most common drugs used to meet the challenges of platelet aggregation. However, these agents face issues with aspirin resistance and bleeding. New therapeutically effective and safe agents are therefore strongly needed, and natural substances could be ideal candidates. Flavonoids, a chemically diverse group of polyphenols, might be important in this regard. Consumption of flavonoids is responsible for several health-promoting properties. A number of flavonoids have shown outstanding preclinical antiplatelet effects through various mechanisms. Flavonoids could provide an ideal approach as templates for new, clinically-effective and safe antiplatelet agents due to their inherent safety and multiple useful pharmacological hits. This review aims to report data from literature regarding flavonoids with antiplatelet activity, with a particular focus on possible mechanisms of action, pharmacokinetic profiles and overall safety, thus providing a strong rationale for the design of selective and well-directed antiplatelet agents of natural origin.

Item Type: Article
Keywords: Antiplatelet Preclinical studies Structure-activity relationship (SAR) studies Pharmacokinetic parameters Safety profile in-vitro platelet-function quercetin glycosides antioxidant activity epigallocatechin gallate myocardial-infarction prenylated flavonoids bioactive flavonoids dietary quercetin oxidative stress Food Science & Technology Toxicology
Divisions:
Page Range: pp. 355-367
Journal or Publication Title: Food and Chemical Toxicology
Journal Index: ISI
Volume: 119
Identification Number: https://doi.org/10.1016/j.fct.2018.02.014
ISSN: 0278-6915
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/3653

Actions (login required)

View Item View Item