Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

STREPTOCOCCUS PNEUMONIAE QUORUM SENSING AND BIOFILM FORMATION ARE AFFECTED BY THYMUS DAENENSIS, SATUREJA HORTENSIS, AND ORIGANUM VULGARE ESSENTIAL OILS

(2018) STREPTOCOCCUS PNEUMONIAE QUORUM SENSING AND BIOFILM FORMATION ARE AFFECTED BY THYMUS DAENENSIS, SATUREJA HORTENSIS, AND ORIGANUM VULGARE ESSENTIAL OILS. Acta Microbiologica Et Immunologica Hungarica. pp. 345-359. ISSN 1217-8950

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Abstract

The aim of this study was to investigate the effect of Thymus daenensis L., Satureja hortensis L., and Origanum vulgare L. essential oils (EOs) on the planktonic growth, biofilm formation, quorum sensing (QS), and competence system (CS) of Streptococcus pneumoniae. The anti-biofilm activity of EOs was determined by Microliter-Plate Test (MtP) and scanning electron microscope (SEM). The QS and CS inhibitory activities were determined on the pre-grown biofilm by gene expression analysis using quantitative real-time RT-PCR. Using gas chromatography-mass spectrometry analysis, the major components of the tested EOs were detected. The MtP and SEM detected a significant inhibitory effect of the three EOs on biofilm formation at sub-minimum inhibitory concentrations (MICs). The most anti-biofilm activity was seen for T. daenensis. LuxS and pfs genes (genes involved in QS) downregulated the following treatment with MIC/2 of Thymus and Satureja EOs. Thymol, carvacrol, p-cymene, pulegone, and 1,8-cineole were the major components of the tested EOs. The used EOs seem to be good candidates for preventing biofilm formation and subsequent colonization of S. pneumoniae. This study introduced T. daenensis and S. hortensis as new anti-biofilm and QS inhibitor agents with a natural origin.

Item Type: Article
Keywords: Streptococcus pneumoniae biofilm formation Thymus daenensis Satureja hortensis Origanum vulgare antimicrobial efficacy staphylococcus-aureus medicinal-plants antibiofilm carriage Immunology Microbiology
Divisions:
Page Range: pp. 345-359
Journal or Publication Title: Acta Microbiologica Et Immunologica Hungarica
Journal Index: ISI
Volume: 65
Number: 3
Identification Number: https://doi.org/10.1556/030.65.2018.013
ISSN: 1217-8950
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/3672

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