Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial

(2018) Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial. Phytotherapy Research. pp. 1382-1387. ISSN 0951-418X

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and is potentially treatable, though there are few therapeutic agents available. Artichoke leaf extract (ALE) has shown potential as a hepatoprotective agent. This study sought to determine if ALE had therapeutic utility in patients with established NAFLD. In this randomized double-blind placebo-controlled parallel-group trial, 100 subjects with ultrasound-diagnosed NAFLD were randomized to either ALE 600mg daily or placebo for a 2-month period. NAFLD response was assessed by liver ultrasound and serological markers including the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio and AST to platelet ratio index (APRI) score. Ninety patients completed the study (49 ALE and 41 placebo) with no side effects reported. ALE treatment compared with placebo: Doppler sonography showed increased hepatic vein flow (p<.001), reduced portal vein diameter (p<.001) and liver size (p<.001), reduction in serum ALT (p<.001) and AST (p<.001) levels, improvement in AST/ALT ratio and APRI scores (p<.01), and reduction in total bilirubin. ALE supplementation reduced total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and triglyceride concentrations (p=.01). This study has shown beneficial effects of ALE supplementation on both ultrasound liver parameters and liver serum parameters (ALT, AST, APRI ratio, and total bilirubin) in patients with NAFLD.

Item Type: Article
Keywords: artichoke leaf extract (ALE) non-alcoholic fatty liver disease (NAFLD) phytochemical placebo-controlled trial chronic hepatitis-c cholesterol curcumin supplementation fibrosis predict health index Pharmacology & Pharmacy
Divisions:
Page Range: pp. 1382-1387
Journal or Publication Title: Phytotherapy Research
Journal Index: ISI
Volume: 32
Number: 7
Identification Number: https://doi.org/10.1002/ptr.6073
ISSN: 0951-418X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/3711

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