(2018) Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation. European Journal of Medicinal Chemistry. pp. 2-28. ISSN 0223-5234
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Abstract
Inflammation comprises the reaction of the body to injury, in which a series of changes of the terminal vascular bed, blood, and connective tissue tends to eliminate the injurious agent and to repair the damaged tissue. It is a complex process, which involves the release of diverse regulatory mediators. The current anti-inflammatory agents are challenged by multiple side effects and thus, new effective therapies are highly needed. The aim of this review is to summarize the described microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors or transcriptional suppressors from medicinal plants, which could be an ideal approach in the management of inflammatory disorders, but need further clinical trials in order to be ultimately validated. (C) 2017 Elsevier Masson SAS. All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | Anti-inflammatory Anti-rheumatism mPGES-1 Enzyme inhibitors Plant-derived compounds prostaglandin e-2 synthase-1 potent 5-lipoxygenase discovery acids biosynthesis expressions derivatives metabolism curcumin Pharmacology & Pharmacy |
| Divisions: | |
| Page Range: | pp. 2-28 |
| Journal or Publication Title: | European Journal of Medicinal Chemistry |
| Journal Index: | ISI |
| Volume: | 153 |
| Identification Number: | https://doi.org/10.1016/j.ejmech.2017.12.059 |
| ISSN: | 0223-5234 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/3743 |
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