Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Clinical evaluation of the anti-inflammatory effects of Heracleum persicum fruits

(2015) Clinical evaluation of the anti-inflammatory effects of Heracleum persicum fruits. Comparative Clinical Pathology. pp. 971-974. ISSN 16185641 (ISSN)

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Inflammation is a key player in the pathophysiology of atherosclerotic cardiovascular disease. Heracleum persicum Desf. Ex Fischer is a medicinal plant containing phytochemicals with anti-inflammatory activity. This study aimed to evaluate the anti-inflammatory effects of H. persicum extract in patients with minimal coronary artery disease. Subjects with <50 luminal narrowing in any of the major coronary arteries in coronary angiography were randomly assigned to H. persicum fruit extract (n = 15; 300 mg/day) or placebo (n = 12) for 6 months. Serum concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8), and C-reactive protein (CRP) were measured at baseline and at the end of study. Serum CRP levels were significantly reduced in both H. persicum (p = 0.007) and placebo (p = 0.035) groups by the end of trial. In contrast, no significant change in serum levels of IL-6 and IL-8 was observed in the study groups (p > 0.05). Comparison of the magnitude of changes between the study groups did not indicate any significant difference between H. persicum extract and placebo (p > 0.05). The present results did not indicate any superior effect of H. persicum to placebo in terms of changing serum levels of inflammatory biomarkers. © 2015, Springer-Verlag London.

Item Type: Article
Keywords: Cardiovascular disease Inflammation Persian hogweed Randomized controlled trial
Page Range: pp. 971-974
Journal or Publication Title: Comparative Clinical Pathology
Journal Index: Scopus
Volume: 24
Number: 4
Identification Number:
ISSN: 16185641 (ISSN)
Depositing User: مهندس مهدی شریفی

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